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Detailed paper information
| Paper title | Phenotypic analysis of Intra-Abdominal Sepsis: A Retrospective observational study |
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| Paper code | A07 |
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| Form of presentation | Oral abstract presentation |
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| Abstract text |
Background: Intra-abdominal sepsis remains a critical challenge in healthcare, contributing significantly to morbidity and mortality among hospitalized patients [1]. Characterized by infection and inflammation within the abdominal cavity, this condition leads to systemic responses and severe complications [2]. Understanding the phenotypic variations in intra-abdominal sepsis and their impact on patient outcomes can enhance management strategies and improve prognosis [3] Message: The aim of the study is to analyze the demographic, clinical, and laboratory parameters of patients with intra-abdominal sepsis, focusing on identifying factors associated with mortality and recovery. In this retrospective observational study of 290 ICU patients with intra-abdominal sepsis (2021–2023), 40% succumbed to the illness, while 60% were discharged. No significant sex-based mortality difference was found. Mortality was significantly associated with vasopressor use (88 vs. 28), elevated heart and respiratory rates, high lactate levels, low pH, and altered mental status. Using multivariate logistic regression, independent predictors of mortality were identified: heart rate (OR: 1.02, p=0.016), respiratory rate (OR: 1.1, p=0.008), vasopressor dosage (OR: 1.07, p=0.025), and GCS score (OR: 0.82, p=0.002). Patients were phenotyped into four categories based on organ dysfunction severity, and outcomes varied by phenotype, particularly among phenotype 3 cases with mixed recovery and death rates. These findings demonstrate that simple, readily available clinical parameters can serve as early predictors of mortality in intra-abdominal sepsis. Impact on Patient Care: The identification of key predictors such as vital signs, vasopressor requirement, and neurological status allows for early risk stratification in patients with intra-abdominal sepsis. This can guide clinical decision-making, optimize resource allocation, and improve the timing of interventions. Phenotyping patients based on organ dysfunction further enables individualized management approaches. These insights support a proactive monitoring strategy and underscore the need for tailored therapies to reduce mortality in this high-risk population. |